Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport
Abstract Background The hormone leptin exerts its function in the brain to reduce food intake and increase energy expenditure to prevent obesity. However, most obese subjects reflect the resistance to leptin even with elevated serum leptin. Considering that leptin must cross the blood–brain barrier...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BMC
2022-09-01
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| Seria: | Fluids and Barriers of the CNS |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1186/s12987-022-00375-3 |
| Etykiety: |
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