Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis

Summary: The role of growth differentiation factor (GDF)-11 in cardiac diseases has not been fully determined. Our study revealed that GDF-11 is not essential for myocardial development and physiological growth, whereas its absence exacerbates heart failure under pressure overload condition via impa...

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Bibliografiske detaljer

Principais autores:	Jinyun Zhu, MD, PhD, Ning Zhang, MD, PhD, Yun Zhao, MD, PhD, Qi Liu, MD, PhD, Yingchao Wang, MD, Mingyao Chen, MD, PhD, Qunchao Ma, MD, PhD, Aiqiang Dong, MD, PhD, Yaping Wang, MD, PhD, Hong Yu, MD, PhD
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2023-06-01
Serier:	JACC: Basic to Translational Science
Fag:	angiogenesis cardiac hypertrophy GDF-11 fibrosis heart failure
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2452302X22004375
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