Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment

Abstract Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease affecting the neuromuscular system. While there have been a number of important genetic discoveries, there are no therapeutics capable of stopping its insidious progression. Lessons from clinical histories reveal that ALS c...

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Detalhes bibliográficos

Principais autores:	Sarah Schram, Jeffrey A. Loeb, Fei Song
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-06-01
coleção:	Journal of Neuroinflammation
Assuntos:	Nerve injury-mediated neuroinflammation Neuronal-glial communication through glial growth factor neuregulin Inhibition of neuregulin-mediated inflammation
Acesso em linha:	http://link.springer.com/article/10.1186/s12974-020-01849-7
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