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A ferritin-targeted biohybrid triggering ferroptosis immunotherapy via activating endogenous iron and replenishing exogenous iron simultaneously

Abstract The key to achieving synergistic ferroptosis immunotherapy is enhancing the iron content in tumor cells, improving specific immunity, and regulating the tumor microenvironment. In this study, a drug-free biohybrid system targeting ferritin is developed using M1 macrophage microvesicles and...

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Hlavní autoři: Shupei Sheng, Yan Zhang, Limin Jin, Weiting Sun, Dunwan Zhu, Lin Mei, Xia Dong, Feng Lv
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2025-07-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-025-61419-4
Tagy: Přidat tag
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