Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase

Background Consumption of aristolochic acids (AA) from the plant Aristolochia results in the formation of bulky aristolactam-dA (dA-AL) and aristolactam-dG (dG-AL) adducts in cellular DNA ultimately leading to the development of urothelial cancer. Intriguingly, the dA-AL adducts induce A•T→T•A trans...

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Detalhes bibliográficos

Principais autores:	Diana Manapkyzy, Gulzhan Zhamanbayeva, Viktoriya Sidorenko, Radha Bonala, Francis Johnson, Bakhyt T. Matkarimov, Dmitry Zharkov, Murat K. Saparbaev, Sabira Taipakova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	PeerJ Inc. 2025-07-01
coleção:	PeerJ
Assuntos:	DNA glycosylase DNA repair Base excision repair Aristolochic acid Aristolactam-adenine adduct T to A transversions
Acesso em linha:	https://peerj.com/articles/19577.pdf
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