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Exosomes overexpressing miR-34c inhibit malignant behavior and reverse the radioresistance of nasopharyngeal carcinoma

Abstract Background Malignant behavior and radioresistance, which severely limits the efficacy of radiation therapy (RT) in nasopharyngeal carcinoma (NPC), are associated with tumor progression and poor prognosis. Mesenchymal stem cells (MSCs) are used as a therapeutic tool in a variety of tumors. T...

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Main Authors: Fang-Zhu Wan, Kai-Hua Chen, Yong-Chu Sun, Xi-Chan Chen, Ren-Ba Liang, Li Chen, Xiao-Dong Zhu
Format: Artigo
Language:Inglês
Published: BMC 2020-01-01
Series:Journal of Translational Medicine
Subjects:
microRNA-34c
β-Catenin
Nasopharyngeal carcinoma
EMT
Radioresistance
Online Access:https://doi.org/10.1186/s12967-019-02203-z
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