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Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for COVID-19 treatment

Aim Insufficient quality control and limited dissolution of Andrographis paniculata extract capsules restricts their bioavailability and hinder the clinical use for treating mild coronavirus disease 2019 (COVID-19) patients.Objective This study aims to investigate pharmacokinetics and safety of high...

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Principais autores: Phanit Songvut, Jaratluck Akanimanee, Tawit Suriyo, Nanthanit Pholphana, Nuchanart Rangkadilok, Duangchit Panomvana, Porranee Puranajoti, Jutamaad Satayavivad
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2025-12-01
Serier:Pharmaceutical Biology
Fag:
Andrographis paniculata ethanolic extract
pharmacokinetics
blood chemistry
safety profiles
andrographolide
Online adgang:https://www.tandfonline.com/doi/10.1080/13880209.2024.2444446
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