STAT3/TGFBI signaling promotes the temozolomide resistance of glioblastoma through upregulating glycolysis by inducing cellular senescence

Abstract Glioblastoma (GBM) is the most lethal type of brain tumor. Recent studies have indicated that cellular senescence-targeted therapy is a promising approach for cancer treatment. However, the underlying mechanisms remain to be clarified. In this study, 101 unique combinations of 10 machine le...

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Hlavní autoři:	Yanbin Zhang, Xiaohua Xiao, Ge Yang, Xiaobing Jiang, Shujie Jiao, Yingli Nie, Tao Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-04-01
Edice:	Cancer Cell International
Témata:	Glioblastoma Senescence Glycolysis Machine learning Prognosis
On-line přístup:	https://doi.org/10.1186/s12935-025-03770-6
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