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Selective loss of TGFbeta Smad-dependent signalling prevents cell cycle arrest and promotes invasion in oesophageal adenocarcinoma cell lines.

In cancer, Transforming Growth Factor beta (TGFbeta) increases proliferation and promotes invasion via selective loss of signalling pathways. Oesophageal adenocarcinoma arises from Barrett's oesophagus, progresses rapidly and is usually fatal. The contribution of perturbed TGFbeta signalling in the...

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Bibliografiske detaljer
Principais autores: Benjamin A Onwuegbusi, Jonathan R E Rees, Pierre Lao-Sirieix, Rebecca C Fitzgerald
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2007-01-01
Serier:PLoS ONE
Online adgang:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000177&type=printable
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