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The NELF pausing checkpoint mediates the functional divergence of Cdk9

Abstract Promoter-proximal pausing by RNA Pol II is a rate-determining step in gene transcription that is hypothesized to be a prominent point at which regulatory factors act. The pausing factor NELF is known to induce and stabilize pausing, but not all kinds of pausing are NELF-mediated. Here, we f...

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I tiakina i:
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Ngā kaituhi matua: Michael DeBerardine, Gregory T. Booth, Philip P. Versluis, John T. Lis
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2023-05-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-023-38359-y
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