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Single-cell and spatial transcriptomics reveal lactylation-associated tumor cell clusters and define a prognostic risk model in glioblastoma

Abstract Background Glioblastoma (GBM) is the most aggressive adult brain tumor, marked by intratumoral heterogeneity and therapy resistance. Metabolic reprogramming through histone lactylation has been linked to tumor progression and immune suppression. However, the spatial and single-cell landscap...

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Principais autores: Rui Han, Guangfan Chi, Dongjie Sun, Ziran Xu, Liangfu Zhou, Kan Xu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-11-01
Serier:BMC Cancer
Fag:
Glioblastoma multiforme
Lactylation
Single-cell RNA sequencing
Spatial transcriptomics
Online adgang:https://doi.org/10.1186/s12885-025-15291-6
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