Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia

Patients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the detrimental treatment side-effects, particularly in children, warr...

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Principais autores:	Mawar Karsa, Emma Ronca, Angelika Bongers, Anna Mariana, Ernest Moles, Timothy W. Failes, Greg M. Arndt, Laurence C. Cheung, Rishi S. Kotecha, Maria Kavallaris, Michelle Haber, Murray D. Norris, Michelle J. Henderson, Lin Xiao, Klaartje Somers
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-01-01
coleção:	Frontiers in Oncology
Assuntos:	KMT2A/MLL-rearranged leukemia infant leukemia repurposing high-throughput screen NR5A1 apoptosis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2021.779859/full
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