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MMPP Exerts Anti-Inflammatory Effects by Suppressing MD2-Dependent NF-κB and JNK/AP-1 Pathways in THP-1 Monocytes

(E)-2-methoxy-4-[3-(4-methoxyphenyl) prop-1-en-1-yl] phenol (MMPP), a novel synthetic analog of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (BHPB), exerts anti-inflammatory and anticancer effects by downregulating the STAT3 pathway. It has also been recently reported that MMPP can act as a PPAR agonist w...

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Principais autores: Seonhwa Kim, Na-Yeon Kim, Jae-Young Park, Hyo-Min Park, Chae-Min Lim, Jinju Kim, Hee Pom Lee, Jin Tae Hong, Do-Young Yoon
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-03-01
Serier:Pharmaceuticals
Fag:
MMPP
lipopolysaccharide
MD2/TLR4
NF-κB
AP-1
Online adgang:https://www.mdpi.com/1424-8247/16/4/480
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