Prostate cancer risk-associated single-nucleotide polymorphisms impact the conformational dynamics of prostate-specific antigen

Abstract Background Two non-synonymous single-nucleotide polymorphisms (SNPs) rs61752561 (D95N substitution) and rs17632542 (I163T substitution) in the KLK3 gene encoding prostate-specific antigen (PSA), a chymotrypsin-like serine protease, are associated with prostate cancer risk and have been show...

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Κύριοι συγγραφείς:	Srilakshmi Srinivasan, Brooke K. Hayes, Mauricio G. S. Costa, Blake T. Riley, Emily Wilson, Emilia M. Marijanovic, Itamar Kass, Hannu Koistinen, David E. Hoke, Judith Clements, Ashley M. Buckle, Jyotsna Batra
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2025-12-01
Σειρά:	BMC Biology
Θέματα:	Prostate cancer Prostate-specific antigen Molecular dynamic simulations Single-nucleotide polymorphism Protein stability Kallikrein-related peptidase
Διαθέσιμο Online:	https://doi.org/10.1186/s12915-025-02458-7
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