Histone demethylase KDM4B epigenetically controls NLRP3 expression to enhance inflammatory responses

Abstract NLRP3 inflammasome, the archetypical molecular driver of inflammation, plays crucial roles in host defense and maintaining cellular homeostasis. Demethylation of histone 3 lysine 9 trimethylation (H3K9me3, the repressive mark for euchromatic genes) is essential for activating gene transcrip...

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Detalhes bibliográficos

Principais autores:	Li Tong, Hui Song, Yuan Gao, Danhui Qin, Caiwei Wang, Qi Li, Yue Fu, Chunyuan Zhao, Zhendong Ying, Dailing Chen, Chengjiang Gao, Chaofeng Han, Wei Zhao, Ying Qin, Lei Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2026-02-01
coleção:	EMBO Molecular Medicine
Assuntos:	NLRP3 KDM4B H3K9me3 Epigenetic Modification NLRP3 Inflammasome
Acesso em linha:	https://doi.org/10.1038/s44321-026-00373-0
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