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Aqueous extract of Amydrium sinense (Engl.) H. Li alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling

Background: The present study aimed to investigate the protective effect of the water extract of Amydrium sinense (Engl.) H. Li (ASWE) against hepatic fibrosis (HF) and clarify the underlying mechanism.Methods: The chemical components of ASWE were analysed by a Q-Orbitrap high-resolution mass spectr...

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Principais autores: Jingyan Li, Bingmin Wu, Lishan Zeng, Ying Lin, Qiuhe Chen, Haixia Wang, Lin An, Jiajun Zhang, Siyan Chen, Junying Huang, Ruoting Zhan, Guifang Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-06-01
Serier:Frontiers in Pharmacology
Fag:
Amydrium sinense
hepatic fibrosis
carbon tetrachloride
α-SMA
Stat3
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2023.1101703/full
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