A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan

BackgroundAging is associated with increased levels of reactive oxygen species and inflammation that disrupt proteostasis and mitochondrial function and leads to organism-wide frailty later in life. ARA290 (cibinetide), an 11-aa non-hematopoietic peptide sequence within the cardioprotective domain o...

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Principais autores:	Nolan M. Winicki, Alay P. Nanavati, Christopher H. Morrell, Jack M. Moen, Jessie E. Axsom, Melissa Krawczyk, Natalia N. Petrashevskaya, Max G. Beyman, Christopher Ramirez, Irene Alfaras, Sarah J. Mitchell, Magdalena Juhaszova, Daniel R. Riordon, Mingyi Wang, Jing Zhang, Anthony Cerami, Michael Brines, Steven J. Sollott, Rafael de Cabo, Edward G. Lakatta
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-01-01
coleção:	Frontiers in Cardiovascular Medicine
Assuntos:	inflammaging longitudinal study cardiovascular aging healthspan frailty cardiac inflammation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcvm.2022.1096887/full
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