Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-<i>N</i>1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship
Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the <i>N</i>1-ribosylated, Ca<sup>2+</sup>-mobilizing, second messenger cyclic adenosine...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI AG
2021-11-01
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| Collection: | Molecules |
| Sujets: | |
| Accès en ligne: | https://www.mdpi.com/1420-3049/26/23/7165 |
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