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Clinical Implications of Promoter Hypermethylation in RASSF1A and MGMT in Retinoblastoma

We investigated the epigenetic silencing and genetic changes of the RAS-associated domain family 1A (RASSF1A) gene and the Os-methylguanine-DNA methyltransferase (MGMT) gene in retinoblastoma. We extracted DNA from microdissected tumor and normal retina tissues of the same patient in 68 retinoblasto...

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Principais autores: Kwong Wai Choy, Tom C. Lee, Kin Fai Cheung, Dorothy S.P. Fan, Kwok Wai Lo, Katherine L. Beaverson, David H. Abramson, Dennis S.C. Lam, Christopher B.O. Yu, Chi Pui Pang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2005-03-01
Serier:Neoplasia: An International Journal for Oncology Research
Fag:
Retinoblastoma
methylation
RASSF1A
MGMT
RB
Online adgang:http://www.sciencedirect.com/science/article/pii/S1476558605800211
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