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Indirubin-3′-monoxime suppresses amyloid-beta- induced apoptosis by inhibiting tau hyperphosphorylation

Indirubin-3′-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer′s disease. Here, we found that indirubin-3′-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta...

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Principais autores: Shu-gang Zhang, Xiao-shan Wang, Ying-dong Zhang, Qing Di, Jing-ping Shi, Min Qian, Li-gang Xu, Xing-jian Lin, Jie Lu
Format: Artigo
Sprog:Inglês
Udgivet: Wolters Kluwer Medknow Publications 2016-01-01
Serier:Neural Regeneration Research
Fag:
nerve regeneration; indirubin-3′-monoxime; amyloid-beta; Alzheimer′s disease; neuronal apoptosis; tau hyperphosphorylation; phosphorylated glycogen synthase kinase-3β; phosphorylated c-Jun N-terminal kinase; neural regeneration
Online adgang:http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=988;epage=993;aulast=Zhang
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