Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A mice

Glutamate-induced excitotoxicity has been suggested to influence pathogenesis in amyotrophic lateral sclerosis (ALS). Vesicular glutamate transporters (VGLUTs) are responsible for transport of glutamate into synaptic vesicles. Nerve terminals that envelop motor neurons in the spinal cord contain VGL...

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Principais autores:	Hanna Wootz, Anders Enjin, Åsa Wallén-Mackenzie, Dan Lindholm, Klas Kullander
格式:	Artigo
语言:	Inglês
出版:	Elsevier 2010-01-01
丛编:	Neurobiology of Disease
主题:	ALS Amyotrophic lateral sclerosis Glutamate Vglut2 Vesicular glutamate transporters Excitotoxicity
在线阅读:	http://www.sciencedirect.com/science/article/pii/S0969996109002472
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