Expanding the scope of PI3K-δ inhibition: Leniolisib treatment in PRKCD deficiencyLeniolisib for the treatment of PRKCD deficiency

Lodi et al. report leniolisib use, a PI3Kδ inhibitor approved for APDS, in a teenager with protein kinase C δ deficiency and progressive multiorgan immune dysregulation. Treatment reduces lymphoproliferation and cytopenias and improves lung and skin disease, showing no drug-related adverse events. T...

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Bibliografiske detaljer

Principais autores:	Lorenzo Lodi, Valentina Guarnieri, Matilde Peri, Manuela Baronio, Silvia Ricci, Clementina Canessa, Francesca Lippi, Marta Voarino, Elisa Calistri, Laura Pisano, Anna Perrone, Grazia Fenu, Giuseppe Indolfi, Vassilios Lougaris, Rebecca A. Marsh, Chiara Azzari
Format:	Artigo
Sprog:	Inglês
Udgivet:	Rockefeller University Press 2026-04-01
Serier:	Journal of Human Immunity
Online adgang:	https://rupress.org/jhi/article-pdf/doi/10.70962/jhi.20250203/2030889/jhi_20250203.pdf
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