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Microglia-derived APOE2 improves remyelination even in the presence of endogenous APOE4

Abstract Demyelination occurs with aging and is exacerbated in neurodegenerative diseases. During demyelination, microglia upregulate expression of APOE, the gene encoding for the brain’s primary lipid transport protein apolipoprotein E (ApoE), which also mediates microglial engulfment and eliminati...

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I tiakina i:
Ngā kaituhi matua: Georgia L. Nolt, Lesley R. Golden, Shealee P. Thorpe, Jessica L. Funnell, Isaiah O. Stephens, Gabriela Hernandez, Steven M. MacLean, Chloe C. Lucido, Chesney R. Brock, Akhil V. Pallerla, Darcy R. Adreon, Holden C. Williams, Josh M. Morganti, Lance A. Johnson
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2025-12-01
Rangatū:Journal of Neuroinflammation
Ngā marau:
Myelination
Microglia
Apolipoprotein E
Gliosis
Lipid metabolism
Brain
Urunga tuihono:https://doi.org/10.1186/s12974-025-03639-5
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