Discovery of facile amides-functionalized rhodanine-3-acetic acid derivatives as potential anticancer agents by disrupting microtubule dynamics

Microtubule dynamics are crucial for multiple cell functions, and cancer cells are particularly sensitive to microtubule-modulating agents. Here, we describe the design and synthesis of a series of (Z)-2-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-N-phenylacetamide derivatives and evaluation of t...

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Detalhes bibliográficos

Principais autores:	Xiang Zhou, Jiamin Liu, Jiao Meng, Yihong Fu, Zhibin Wu, Guiping Ouyang, Zhenchao Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2021-01-01
coleção:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	microtubule antiproliferative activity tubulin stabiliser taxol binding domains
Acesso em linha:	http://dx.doi.org/10.1080/14756366.2021.1975695
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