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A predictive in vitro model of the impact of drugs with anticholinergic properties on human neuronal and astrocytic systems.

The link between off-target anticholinergic effects of medications and acute cognitive impairment in older adults requires urgent investigation. We aimed to determine whether a relevant in vitro model may aid the identification of anticholinergic responses to drugs and the prediction of anticholiner...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Elizabeth K Woehrling, H Rheinallt Parri, Erin H Y Tse, Eric J Hill, Ian D Maidment, G Christopher Fox, Michael D Coleman
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2015-01-01
Schriftenreihe:PLoS ONE
Online-Zugang:https://doi.org/10.1371/journal.pone.0118786
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