Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression

Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high metastasis and therapeutic resistance. Activating transcription factor 4 (ATF4), a master regulator of cellular stress, is exploited by cancer cells to survive. Prior research and data reported provide evidence that h...

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Principais autores:	Debasmita Mukherjee, Srija Chakraborty, Lena Bercz, Liliana D’Alesio, Jessica Wedig, Molly A. Torok, Timothy Pfau, Hannah Lathrop, Shrina Jasani, Abigail Guenther, Jake McGue, Daniel Adu-Ampratwum, James R. Fuchs, Timothy L. Frankel, Maciej Pietrzak, Stacey Culp, Anne M. Strohecker, Aleksander Skardal, Thomas A. Mace
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2023-08-01
叢編:	iScience
主題:	Therapeutics Microenvironment Cancer
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2589004223014852
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