Overexpression of bovine FcRn in mice enhances T-dependent immune responses by amplifying T helper cell frequency and germinal center enlargement in the spleen

The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transport and antigen presentation of IgG-opsonized antigens. Previously we reported that transgenic (Tg) mice that overexpress the bovine FcRn (bFcRn) have augmented T dependent humoral immune response with...

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Bibliografski detalji

Glavni autori:	Zita eSchneider, Péter Károly Jani, Szikora eBence, Attila eVégh, Dorottya eKövesdi, Attila eIliás, Judit eCervenak, Péter eBalogh, István eKurucz, Imre eKacskovics
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2015-07-01
Serija:	Frontiers in Immunology
Teme:	Antigen Presentation Germinal Center Humoral Immune Response FcRn overexpression humoral immune diversity
Online pristup:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00357/full
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