Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure

Summary: Pediatric high-grade gliomas (pHGGs) are among the most lethal childhood tumors. While therapeutic approaches were largely adapted from adult treatment regime, significant biological differences between pediatric and adult gliomas exist, which influence the immune microenvironment and may c...

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Autores principales:	Jenna J. LaBelle, Rebecca D. Haase, Alexander Beck, Jacob Haase, Li Jiang, Carlos Alberto Oliveira de Biagi, Jr., Sina Neyazi, Bernhard Englinger, Ilon Liu, Maria Trissal, Daeun Jeong, Olivia A. Hack, Andrezza Nascimento, McKenzie L. Shaw, Cuong M. Nguyen, Sophia Castellani, Nathan D. Mathewson, Orr Ashenberg, Gustavo Alencastro Veiga Cruzeiro, Tom Rosenberg, Jayne R. Vogelzang, Jason Pyrdol, Sascha Marx, Adrienne M. Luomo, Anze Godicelj, Alicia Baumgartner, Jacob S. Rozowsky, Sibylle Madlener, Lisa Mayr, Andreas Peyrl, Rene Geyeregger, Daniela Loetsch, Christian Dorfer, Christine Haberler, Natalia Stepien, Irene Slavc, Tom Belle Davidson, Robert M. Prins, Kee Kiat Yeo, Tabitha Cooney, Keith Ligon, Hart Lidov, Sanda Alexandrescu, Lissa C. Baird, Johannes Gojo, Kai W. Wucherpfennig, Mariella G. Filbin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2025-05-01
Colección:	Cell Reports Medicine
Materias:	immuno-oncology tumor microenvironment single-cell RNA-seq pediatric high-grade glioma tumor-infiltrating immune cell biology
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2666379125001685
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