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AAV9 targets cone photoreceptors in the nonhuman primate retina.

Transduction of retinal pigment epithelial cells with an adeno-associated viral vector (AAV) based on serotype 2 has partially corrected retinal blindness in Leber congenital amaurosis type 2. However, many applications of gene therapy for retinal blindness rely on the efficient transduction of rod...

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Principais autores: Luk H Vandenberghe, Peter Bell, Albert M Maguire, Ru Xiao, Tim B Hopkins, Rebecca Grant, Jean Bennett, James M Wilson
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC3559681?pdf=render
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