Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis. Mechanisms of IL-1β secretion by pyroptotic and non-pyroptotic ...

Volledige beschrijving

Bibliografische gegevens

Hoofdauteurs:	Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Elsevier 2018-08-01
Reeks:	Cell Reports
Online toegang:	http://www.sciencedirect.com/science/article/pii/S2211124718311173
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!