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Design, Synthesis and Biological Assessment of Rhodanine-Linked Benzenesulfonamide Derivatives as Selective and Potent Human Carbonic Anhydrase Inhibitors

A novel series of twenty-five rhodamine-linked benzenesulfonamide derivatives (<b>7a</b>–<b>u</b> and <b>9a</b>–<b>d</b>) were synthesized and screened for their inhibitory action against four physiologically relevant human (h) carbonic anhydrase (CA) isoforms, namely hCA I, hCA II, hCA IX, and hCA...

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Principais autores: Baijayantimala Swain, Abrar Khan, Priti Singh, Vaibhav S. Marde, Andrea Angeli, Krishna Kartheek Chinchilli, Venkata Madhavi Yaddanapudi, Simone Carradori, Claudiu T. Supuran, Mohammed Arifuddin
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-11-01
Serier:Molecules
Fag:
rhodanine
carbonic anhydrase
isoform selectivity
benzenesulfonamide
enzyme inhibition
Online adgang:https://www.mdpi.com/1420-3049/27/22/8028
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