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Systematic transcriptome profiling of pyroptosis related signature for predicting prognosis and immune landscape in lower grade glioma

Abstract Background Pyroptosis is a programmed cell death mediated by the gasdermin superfamily, accompanied by inflammatory and immune responses. Exogenously activated pyroptosis is still not well characterized in the tumor microenvironment. Furthermore, whether pyroptosis-related genes (PRGs) in l...

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Main Authors: Huihan Yu, Meiting Gong, Jian Qi, Chenggang Zhao, Wanxiang Niu, Suling Sun, Shuyang Li, Bo Hong, Junchao Qian, Hongzhi Wang, Xueran Chen, Zhiyou Fang
Format: Artigo
Language:Inglês
Published: BMC 2022-08-01
Series:BMC Cancer
Subjects:
Pyroptosis
Lower-grade glioma
Prognostic signature
Tumor immune microenvironment
Drug screening
Fedratinib
Online Access:https://doi.org/10.1186/s12885-022-09982-7
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