An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy

STING-associated vasculopathy with onset in infancy (SAVI) is an autoimmune disease caused by gain-of-function mutations (GOFs) of MITA/STING and the most frequent GOFs for SAVI are MITAN154S and MITAV155M. However, how MITA GOFs are spontaneously activated remains incompletely understood. Here, we...

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Autors principals:	Fang-Xu Li, Sheng Liu, Zhi-Dong Zhang, Xin Shuai, Bi-Kun Xiao, Jia Yang, Defen Lu, Dandan Lin, Guijun Shang, Bo Zhong
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-02-01
Col·lecció:	Cell Insight
Matèries:	SAVI MITA/STING MITA gain-of-function mutations ER-To-Golgi translocation SAVI-Inhibitory peptide Therapeutic intervention
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2772892726000015
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