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HEYL Regulates Neoangiogenesis Through Overexpression in Both Breast Tumor Epithelium and Endothelium

Blocking tumor angiogenesis is an appealing therapeutic strategy, but to date, success has been elusive. We previously identified HEYL, a downstream target of Notch signaling, as an overexpressed gene in both breast cancer cells and as a tumor endothelial marker, suggesting that HEYL overexpression...

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Principais autores: Liangfeng Han, Preethi Korangath, Nguyen K. Nguyen, Adam Diehl, Soonweng Cho, Wei Wen Teo, Leslie Cope, Manfred Gessler, Lewis Romer, Saraswati Sukumar
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-01-01
coleção:Frontiers in Oncology
Assuntos:
breast
cancer
endothelium
HEYL
notch
cytokines
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2020.581459/full
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