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Site-specific neoepitope induction by RNA editing reprograms tumor immunogenicity

IntroductionNeoantigens derived from somatic mutations exhibit high immunogenicity and specificity. However, their stochastic nature necessitates personalized vaccine design, and cancers with low tumor mutational burden often have insufficient neoantigen availability, limiting their clinical applica...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Shangyuan Liu, Chunxiu Dong, Lin Chen, Jiahong Yan, Xiaoshan Luo, HaiChao Huang, Zonghao Qiu, Xuhong Gan, Jiali Yang, Jiafeng Zhu, Chengjie Xiong, Lihong Huang, Linlin Wang, Zhengning Yang, Zhongxuan Meng, Senrong Yi, Yuxin Chen, Chijian Zuo, Qibin Leng, Xiaoling Wang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2026-06-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
RNA editing
neoantigen
ADAR
epitope
tumor immunogenicity
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1839930/full
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