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Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications

Abstract Complex crosstalk occurs between protein and nucleic acid modifications, with lactylation, an emerging post-translational modification (PTM), being implicated in tumor progression. However, the mechanisms mediating the crosstalk between lactylation and RNA modifications and their roles in d...

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Principais autores: Shantong Liu, Qianquan Ma, Chong Zeng, Haoyu Li, Jun Su, Zhihao Song, Ruyu Yan, Zijin Zhao, Songhai Tian, Wei Huang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-08-01
coleção:Biomarker Research
Assuntos:
Lactylation modification
RNA modification
Crosstalk
Positive feedback loop
Targeted therapy
Acesso em linha:https://doi.org/10.1186/s40364-025-00824-9
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