Parenteral platforms for tunable, long-acting administration of a highly hydrophobic antiretroviral drug

Abstract GSK2838232 (GSK8232) is a second-generation maturation inhibitor (MI) developed for the treatment of HIV with excellent broad-spectrum virological profiles. The compound has demonstrated promising clinical results as an orally administered agent. Additionally, the compound’s physical and ph...

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Hlavní autoři:	Nima Akhavein, Marc M. Baum, Manjula Gunawardana, John A. Moss, Sandrine Calvez, Mariana Remedios-Chan, Rob Fanter, Steve Lenhard, Samantha Rusk, Leonard Azzarano, Deborah McCoy, Beat Jucker, Brian Johns, Matt Burke, Emile Velthuisen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-05-01
Edice:	Scientific Reports
Témata:	Maturation inhibitor Sustained release drug delivery Long-acting HIV treatment HIV PrEP Ionic liquids Subdermal implants
On-line přístup:	https://doi.org/10.1038/s41598-024-58583-w
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