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Dapagliflozin in Chronic Kidney Disease: Insights from Network Pharmacology and Molecular Docking Simulation

Chronic kidney disease (CKD) involves inflammation, oxidative stress, and fibrosis, leading to renal dysfunction. Dapagliflozin, an SGLT2 inhibitor, shows renoprotective effects beyond glucose control, but its precise molecular mechanisms remain unclear. This study utilizes network pharmacology and...

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Principais autores: Atthaphong Phongphithakchai, Aman Tedasen, Ratana Netphakdee, Rattana Leelawattana, Thatsaphan Srithongkul, Sukit Raksasuk, Jason C. Huang, Moragot Chatatikun
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-03-01
Serier:Life
Fag:
dapagliflozin
chronic kidney disease
network pharmacology
molecular docking
protein-protein interaction
Online adgang:https://www.mdpi.com/2075-1729/15/3/437
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