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SPP1+macrophages promote fibroblast-to-myofibroblast transformation during hypoxia in deep fascia of acute compartment syndrome

BackgroundAcute compartment syndrome (ACS) is a life-threatening condition characterized by elevated intracompartmental pressure leading to ischemia, hypoxia and tissue necrosis. We have observed an increase in SPP1+macrophages and fibroblast activation in the deep fascia of ACS patients. However, t...

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Principais autores: Liujie Zheng, Guoqiang Li, Jingcheng Cao, Zihang Zhao, Haofei Wang, Qi Dong, Zhiyong Hou
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2025-10-01
סדרה:Frontiers in Immunology
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גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1588926/full
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