Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1

<b>Background</b>: Eukaryotic topoisomerase 1 is a potential target of anti-parasitic and anti-cancer drugs. Parasites require topoisomerase 1 activity for survival and, consequently, compounds that inhibit topoisomerase 1 activity may be of interest. All effective topoisomerase 1 drugs with anti-ca...

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Bibliografiske detaljer

Principais autores:	Kamilla Vandsø Petersen, Asier Selas, Kirstine Mejlstrup Hymøller, Karol Mizielinski, Maria Thorsager, Magnus Stougaard, Concepcion Alonso, Francisco Palacios, Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Birgitta R. Knudsen, Cinzia Tesauro
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2021-08-01
Serier:	Pharmaceutics
Fag:	topoisomerase 1 REEAD rolling circle amplification small-molecule compounds drug screening enzyme activity
Online adgang:	https://www.mdpi.com/1999-4923/13/8/1255
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