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Integration of single-cell and bulk RNA-seq via machine learning to reveal ferroptosis- and lipid metabolism-driven immune landscape heterogeneity and predict immunotherapy response in colon cancer

ObjectiveThis study explored the interactions between ferroptosis and lipid metabolism in colon cancer, established a prognostic model to elucidate immune microenvironment heterogeneity, and evaluated the prospects of immunotherapy.MethodsTranscriptome sequencing and single-cell transcriptome data f...

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Principais autores: Weifeng Wang, Xuanhao Lin, Chufa Zheng, Peixiu Yao, Dejin Xie, Yiyan Lin, Xiaozhong Wang, Weiqin Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-12-01
coleção:Frontiers in Immunology
Assuntos:
colon cancer
ferroptosis
immunotherapy
lipid metabolism
prognostic signature
single-cell analysis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1699079/full
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