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TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation

Women with autoimmune and inflammatory aetiologies can exhibit reduced fecundity. TNFAIP3 is a master negative regulator of inflammation, and has been linked to many inflammatory conditions by genome wide associations studies, however its role in fertility remains unknown. Here we show that mice har...

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Principais autores: Nathan W. Zammit, Joseph McDowell, Joanna Warren, Walter Muskovic, Joanne Gamble, Yan-Chuan Shi, Dominik Kaczorowski, Chia-Ling Chan, Joseph Powell, Chris Ormandy, David Brown, Samantha R. Oakes, Shane T. Grey
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
coleção:Frontiers in Immunology
Assuntos:
TNFAIP3
A20
inflammation
reproduction
fertility
neuroinflammation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.811525/full
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