Effects of Arylsulfatase B and Pembrolizumab in combination on progression of metastatic melanoma in the B16F10 syngeneic mouse model

In this report, experiments assessed how Arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) treatment might interact with Pembrolizumab and improve therapeutic responses in melanoma. ARSB acts to remove 4-sulfate groups from chondroitin 4-sulfate (C4S; chondroitin sulfate A; CSA). ARSB is req...

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Hlavní autoři:	Sumit Bhattacharyya, Insug O-Sullivan, Joanne K. Tobacman
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-06-01
Edice:	Frontiers in Oncology
Témata:	apoptosis Arylsulfatase B checkpoint inhibition chondroitin 4-sulfate invasiveness melanoma
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1820206/full
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