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CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC

Abstract The spindle assembly checkpoint (SAC) ensures chromosome segregation fidelity by manipulating unattached kinetochore‐dependent assembly of the mitotic checkpoint complex (MCC). The MCC binds to and inhibits the anaphase promoting complex/cyclosome (APC/C) to postpone mitotic exit. However,...

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Principais autores: Qi Li, Qingzhou Chen, Tao Zheng, Fulin Wang, Junlin Teng, Haining Zhou, Jianguo Chen
Formato: Artigo
Idioma:Inglês
Publicado: Wiley 2024-09-01
Series:Advanced Science
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Acceso en liña:https://doi.org/10.1002/advs.202406009
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