Impact of primary resistance to front-line targeted therapy in metastatic renal cell carcinoma on subsequent immune-checkpoint-inhibition

Abstract Introduction Synergistic effects have been discussed for tyrosine kinase (TKI) and immune checkpoint inhibitors (ICI). Primary resistance to TKI might disturb subsequent ICI effectiveness. The objective was to investigate, if primary resistance to 1st line TKI monotherapy predicts response...

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Autors principals:	J. H. Börner, S. Neuberger, E. Juengel, S. Ziewers, R. Dotzauer, P. Sparwasser, T. Höfner, I. Tsaur, A. Haferkamp, R. Mager
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer 2023-09-01
Col·lecció:	Discover Oncology
Matèries:	Metastatic renal cell carcinoma Resistance Sequential therapy Anti-VEGF Immune checkpoint inhibition
Accés en línia:	https://doi.org/10.1007/s12672-023-00791-3
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