High resolution crystal structure of human β-glucuronidase reveals structural basis of lysosome targeting.

Human β-glucuronidase (GUS) cleaves β-D-glucuronic acid residues from the non-reducing termini of glycosaminoglycan and its deficiency leads to mucopolysaccharidosis type VII (MPSVII). Here we report a high resolution crystal structure of human GUS at 1.7 Å resolution and present an extensive analys...

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Bibliografiske detaljer

Principais autores:	Md Imtaiyaz Hassan, Abdul Waheed, Jeffery H Grubb, Herbert E Klei, Sergey Korolev, William S Sly
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2013-01-01
Serier:	PLoS ONE
Online adgang:	http://europepmc.org/articles/PMC3834196?pdf=render
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