Combining BET inhibition with SMAC mimetics restricts tumor growth and triggers immune surveillance in preclinical cancer models

Summary: Second mitochondrial activator of caspase (SMAC) mimetics (SMACm) and bromodomain and extra-terminal domain (BET) inhibitors (BETi) are two distinct classes of novel anticancer therapeutics. So far, broad clinical benefit for either monotherapy has not been achieved, calling for effective c...

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Główni autorzy:	Ksenija Slavic Obradovic, Florian Ebner, Artem V. Artemov, Martina Miotto, Paula-Elena Traexler, Robin Jacob, Ha Pham Thi Thanh, Regina Ruzicka, Andreas Wernitznig, Ines Baumann, Daniel Gerlach, Maria-Antonietta Impagnatiello, Salvatore Siena, Mary Murphy, Reniqua House, Ulrich Reiser, Valeria Santoro, Johannes Popow, Sebastian Carotta, Anke Baum, Jesse Lipp, Alberto Bardelli, Ulrike Tontsch-Grunt, Mariangela Russo, Martin Aichinger
Format:	Artigo
Język:	Inglês
Wydane:	Elsevier 2025-09-01
Seria:	Cell Reports Medicine
Hasła przedmiotowe:	SMAC mimetic cIAP BET inhibition cell death tumor microenvironment combination therapy
Dostęp online:	http://www.sciencedirect.com/science/article/pii/S2666379125003866
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