Collateral Arteriogenesis Involves a Sympathetic Denervation That Is Associated With Abnormal α-Adrenergic Signaling and a Transient Loss of Vascular Tone

Stimulating collateral arteriogenesis is an attractive therapeutic target for peripheral artery disease (PAD). However, the potency of arteriogenesis-stimulation in animal models has not been matched with efficacy in clinical trials. This may be because the presence of enlarged collaterals is not su...

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Principais autores:	Alexander Silva, Christopher J. Hatch, Megan T. Chu, Trevor R. Cardinal
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-02-01
coleção:	Frontiers in Cardiovascular Medicine
Assuntos:	arteriogenesis vasodilation vascular tone sympathetic adrenergic ischemia
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcvm.2022.805810/full
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