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The effect of drug ionization on lipid-based formulations for the oral delivery of anti-psychotics

Lipid-based formulations (LBFs) are well-known to improve the oral bioavailability of poorly water-soluble drugs (PWSDs) by presenting the drug to the gastrointestinal environment in a molecularly dispersed state, thus avoiding the rate-limiting dissolution step. Risperidone and lurasidone are antip...

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Hlavní autoři: Tahlia R Meola, Kara Paxton, Paul Joyce, Hayley B Schultz, Clive A Prestidge
Médium: Artigo
Jazyk:Inglês
Vydáno: International Association of Physical Chemists (IAPC) 2020-07-01
Edice:ADMET and DMPK
On-line přístup:https://pub.iapchem.org/ojs/index.php/admet/article/view/830
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