Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo

SLAMF1-derived peptide P7 inhibits TLR4-mediated signaling and prevents animal death in mice subjected to LPS shock by blocking TIRAP–MyD88 interaction and TRAM recruitment to TLR4. Inflammation plays a crucial role in the development and progression of many diseases, and is often caused by dysregul...

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Autores principales:	Kaja Elisabeth Nilsen, Boyao Zhang, Astrid Skjesol, Liv Ryan, Hilde Vagle, Maren Helene Bøe, Pontus Orning, Hera Kim, Siril Skaret Bakke, Kirusika Elamurugan, Ingvild Bergdal Mestvedt, Jørgen Stenvik, Harald Husebye, Egil Lien, Terje Espevik, Maria Yurchenko
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Life Science Alliance LLC 2023-12-01
Colección:	Life Science Alliance
Acceso en línea:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202302164
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